Assay Detail
Binding
CHEMBL4737367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ZM241385 from A2A receptor in rat brain corpora striata incubated for 70 mins by liquid scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of Tozadenant analogues as adenosine A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.54 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4746388 | — | — | 1 | 7.83 |
| CHEMBL2105747 | TOZADENANT | 3.0 | 1 | 7.73 |
| CHEMBL4783723 | — | — | 1 | 7.72 |
| CHEMBL4753657 | — | — | 1 | 7.69 |
| CHEMBL4746896 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4746388 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL2105747 | TOZADENANT | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL4783723 | — | Ki | = | 19.2 | nM | 7.72 |
| CHEMBL4753657 | — | Ki | = | 20.4 | nM | 7.69 |
| CHEMBL4746896 | — | Ki | = | 195.0 | nM | 6.71 |