Assay Detail
Binding
CHEMBL4738759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR4 (unknown origin)
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of indazole derivatives as selective and potent FGFR4 inhibitors for the treatment of FGF19-driven hepatocellular cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.88 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4779598 | — | — | 1 | 8.25 |
| CHEMBL4068896 | — | — | 1 | 8.20 |
| CHEMBL4748343 | — | — | 1 | 8.17 |
| CHEMBL4757428 | — | — | 1 | 8.07 |
| CHEMBL4795133 | — | — | 1 | 7.22 |
| CHEMBL4791462 | — | — | 1 | 7.00 |
| CHEMBL4751903 | — | — | 1 | 6.92 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 6.62 |
| CHEMBL4796363 | — | — | 1 | 6.59 |
| CHEMBL4761494 | — | — | 1 | 6.56 |
| CHEMBL4754648 | — | — | 1 | 6.52 |
| CHEMBL4755247 | — | — | 1 | 6.43 |
| CHEMBL4765104 | — | — | 1 | 6.37 |
| CHEMBL4743257 | — | — | 1 | 6.35 |
| CHEMBL4744134 | — | — | 1 | 6.35 |
| CHEMBL4760869 | — | — | 1 | 6.20 |
| CHEMBL4751708 | — | — | 1 | 6.14 |
| CHEMBL4800539 | — | — | 1 | 5.94 |
| CHEMBL4751993 | — | — | 1 | - |
| CHEMBL4740779 | — | — | 1 | - |
| CHEMBL4784126 | — | — | 1 | - |
| CHEMBL4758831 | — | — | 1 | - |
| CHEMBL4747852 | — | — | 1 | - |
| CHEMBL4793410 | — | — | 1 | - |
| CHEMBL4762574 | — | — | 1 | - |
| CHEMBL4747265 | — | — | 1 | - |
| CHEMBL4785890 | — | — | 1 | - |
| CHEMBL4751385 | — | — | 1 | - |
| CHEMBL4741627 | — | — | 1 | - |
| CHEMBL4745994 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4779598 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4068896 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4748343 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4757428 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4795133 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4791462 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4751903 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4796363 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL4761494 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL4754648 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL4755247 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL4765104 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL4743257 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL4744134 | — | IC50 | = | 449.0 | nM | 6.35 |
| CHEMBL4760869 | — | IC50 | = | 632.0 | nM | 6.20 |
| CHEMBL4751708 | — | IC50 | = | 726.0 | nM | 6.14 |
| CHEMBL4800539 | — | IC50 | = | 1137.0 | nM | 5.94 |
| CHEMBL4746506 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4747930 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4785241 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4795795 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4746571 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4764232 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4756999 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4745994 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4741627 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4751385 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4785890 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4747265 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4762574 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4793410 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4747852 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4758831 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4784126 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4740779 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL4751993 | — | IC50 | > | 1500.0 | nM | - |