Assay Detail
Binding
CHEMBL4739015
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Inhibition of human recombinant CLK1 using ERMRPRKRQGSVR substrate by radiometric scintillation assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK1 (CHEMBL4224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.95 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754195 | — | — | 1 | 8.10 |
| CHEMBL4762964 | — | — | 1 | 7.85 |
| CHEMBL4789951 | — | — | 1 | 7.80 |
| CHEMBL4797457 | — | — | 1 | 7.75 |
| CHEMBL4791451 | — | — | 1 | 7.23 |
| CHEMBL4743730 | — | — | 1 | 7.17 |
| CHEMBL4778370 | — | — | 1 | 6.94 |
| CHEMBL4741919 | — | — | 1 | 6.77 |
| CHEMBL4740998 | — | — | 1 | 6.51 |
| CHEMBL4789373 | — | — | 1 | 6.35 |
| CHEMBL4794825 | — | — | 1 | 6.17 |
| CHEMBL4777288 | — | — | 1 | 6.02 |
| CHEMBL4777540 | — | — | 1 | 5.67 |
| CHEMBL4758047 | — | — | 1 | - |
| CHEMBL4747210 | — | — | 1 | - |
| CHEMBL4790254 | — | — | 1 | - |
| CHEMBL4800422 | — | — | 1 | - |
| CHEMBL4793177 | — | — | 1 | - |
| CHEMBL4777533 | — | — | 1 | - |
| CHEMBL4747520 | — | — | 1 | - |
| CHEMBL4795812 | — | — | 1 | - |
| CHEMBL4778153 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754195 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4762964 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4789951 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4797457 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4791451 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4743730 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4778370 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4741919 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4740998 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL4789373 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4794825 | — | IC50 | = | 671.0 | nM | 6.17 |
| CHEMBL4777288 | — | IC50 | = | 946.0 | nM | 6.02 |
| CHEMBL4777540 | — | IC50 | = | 2112.0 | nM | 5.67 |
| CHEMBL4758047 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4747210 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4790254 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4800422 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4793177 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4777533 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4747520 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4795812 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4778153 | — | IC50 | > | 3000.0 | nM | - |