Assay Detail
ADMET
CHEMBL4739222
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C9 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel monocyclic amide-linked phenol derivatives without mitochondrial toxicity have potent uric acid-lowering activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.24 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 7.39 |
| CHEMBL4594446 | DOTINURAD | 3.0 | 1 | 5.24 |
| CHEMBL4744272 | — | — | 1 | 4.28 |
| CHEMBL4751546 | — | — | 1 | 4.03 |
| CHEMBL4794079 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4594446 | DOTINURAD | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4744272 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL4751546 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL4794079 | — | IC50 | > | 100000.0 | nM | - |