Assay Detail
Binding
CHEMBL4739819
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CLK3 (unknown origin) using Ser/Thr 18 peptide as substrate incubated for 1 hr in presence of ATP by FRET assay
641
Total Activities
641
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK3 (CHEMBL4226) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Methods of treating cartilage disorders through inhibition of clk and dyrk
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 641 | 6.87 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4748515 | — | — | 1 | 8.52 |
| CHEMBL4761662 | — | — | 1 | 8.22 |
| CHEMBL4740064 | — | — | 1 | 8.15 |
| CHEMBL4746469 | — | — | 1 | 8.15 |
| CHEMBL4782826 | — | — | 1 | 8.10 |
| CHEMBL4754110 | — | — | 1 | 8.05 |
| CHEMBL4741472 | — | — | 1 | 8.05 |
| CHEMBL4745584 | — | — | 1 | 8.05 |
| CHEMBL4798969 | — | — | 1 | 8.00 |
| CHEMBL4761354 | — | — | 1 | 7.96 |
| CHEMBL4780537 | — | — | 1 | 7.96 |
| CHEMBL4797241 | — | — | 1 | 7.96 |
| CHEMBL4780597 | — | — | 1 | 7.96 |
| CHEMBL4748995 | — | — | 1 | 7.96 |
| CHEMBL4779592 | — | — | 1 | 7.96 |
| CHEMBL4752625 | — | — | 1 | 7.92 |
| CHEMBL4793171 | — | — | 1 | 7.92 |
| CHEMBL4741101 | — | — | 1 | 7.92 |
| CHEMBL4800068 | — | — | 1 | 7.92 |
| CHEMBL4784318 | CIRTUVIVINT | 1.0 | 1 | 7.92 |
| CHEMBL4786746 | — | — | 1 | 7.92 |
| CHEMBL4783783 | — | — | 1 | 7.92 |
| CHEMBL4742870 | — | — | 1 | 7.89 |
| CHEMBL4746668 | — | — | 1 | 7.89 |
| CHEMBL4755579 | — | — | 1 | 7.89 |
| CHEMBL4742725 | — | — | 1 | 7.85 |
| CHEMBL4788275 | — | — | 1 | 7.85 |
| CHEMBL4748484 | — | — | 1 | 7.85 |
| CHEMBL4799760 | — | — | 1 | 7.85 |
| CHEMBL4759361 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4748515 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4761662 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4746469 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4740064 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4782826 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4754110 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4745584 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4741472 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4798969 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4748995 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4780597 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4797241 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4780537 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4779592 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4761354 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4741101 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4800068 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4752625 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4784318 | CIRTUVIVINT | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4793171 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4783783 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4786746 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4746668 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4742870 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4755579 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4748484 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4799760 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4742725 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4788275 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4759361 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4740518 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4747740 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4745415 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4748909 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4800405 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4786564 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4786934 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4745260 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4791409 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4777070 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4749420 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4779458 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4758853 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4755351 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4758175 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4788867 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4764806 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4795948 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4750609 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4797292 | — | EC50 | = | 19.0 | nM | 7.72 |