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Compound Detail

CHEMBL4799760

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Cc1nnc(-c2ccc3cnc(NC(=O)c4ccnc(C5=CCN(C)CC5)c4)cc3c2)s1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4799760
Phase Preclinical
Structure Type MOL
InChI Key FODAKPNZAKJZKF-UHFFFAOYSA-N
6
Targets
13
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

442.6
MW (Da)
4.43
ALogP
7
HBA
1
HBD
83.9
PSA (Ų)
0.50
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H22N6OS
MW 442.55
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -1.19

Activity Summary

EC50 13 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Dual specificity protein kinase CLK2
CHEMBL4225
 EC50 8.7 8.7 2.0 1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CHEMBL2292
 EC50 8.6 8.584 2.5 5
Dual specificity protein kinase CLK3
CHEMBL4226
 EC50 7.85 7.85 14.0 1
Proto-oncogene Wnt-1
CHEMBL1255129
 EC50 7.39 7.39 41.0 1
Unchecked
CHEMBL612545
 EC50 7.39 7.115 40.9 2
Glycogen synthase kinase-3 beta
CHEMBL262
 EC50 6.62 6.62 242.0 3

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Dual specificity protein kinase CLK2 EC50 = 2.0 nM 8.7 Inhibition of recombinant CLK2 (unknown origin) using Ser/Thr 6 peptide as subst... -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A EC50 = 2.5 nM 8.6 The DYRK1A kinase assa: Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr pept... -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A EC50 = 2.5 nM 8.6 Kinase Assay: The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyt... -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A EC50 = 2.5 nM 8.6 The DYRKIA kinase assay: The DYRKIA kinase assay was run using the Ser/Thr 18 pe... -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A EC50 = 2.5 nM 8.6 DYRKIA Kinase Activity Assay: The DYRKIA kinase assay was run using the Ser/Thr ... -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A EC50 = 3.0 nM 8.52 Inhibition of recombinant DYRK1A (unknown origin) using Ser/Thr 18 peptide as su... -
Dual specificity protein kinase CLK3 EC50 = 14.0 nM 7.85 Inhibition of recombinant CLK3 (unknown origin) using Ser/Thr 18 peptide as subs... -
Unchecked EC50 = 40.9 nM 7.39 Effect on Wnt signaling pathway in human SW480 cells harbouring TCF/LEF lucifera... -
Proto-oncogene Wnt-1 EC50 = 41.0 nM 7.39 The screening assay for Wnt activity: The screening assay for Wnt activity is de... -
Unchecked EC50 = 143.4 nM 6.84 Inhibition of IL1-beta induced MMP3 expression levels in human chondrocytes asse... -
Glycogen synthase kinase-3 beta EC50 = 242.0 nM 6.62 GSK3 beta kinase assay: Briefly, recombinant GSK3β kinase, ATP and Ser/Thr pepti... -
Glycogen synthase kinase-3 beta EC50 = 242.0 nM 6.62 Kinase Assay: The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte ... -
Glycogen synthase kinase-3 beta EC50 = 242.0 nM 6.62 The GSK3beta kinase assay: The GSK3β kinase assay is run using the Ser/Thr 09 pe... -

Data from ChEMBL 36 via Core Engine