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Compound Detail

CHEMBL4755579

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CC(C)n1cc(C(=O)Nc2cc3cc(-c4cncn4C)ccc3cn2)cn1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4755579
Phase Preclinical
Structure Type MOL
InChI Key OILVNOZMRVRMFV-UHFFFAOYSA-N
5
Targets
9
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

360.4
MW (Da)
3.67
ALogP
6
HBA
1
HBD
77.6
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H20N6O
MW 360.42
Aromatic Rings 4
Heavy Atoms 27
NP-Likeness -1.33

Activity Summary

EC50 9 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Dual specificity protein kinase CLK2
CHEMBL4225
 EC50 9.0 9.0 1.0 1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CHEMBL2292
 EC50 8.7 8.3467 2.0 3
Dual specificity protein kinase CLK3
CHEMBL4226
 EC50 7.89 7.89 13.0 1
Unchecked
CHEMBL612545
 EC50 7.46 6.65 34.8 2
Glycogen synthase kinase-3 beta
CHEMBL262
 EC50 5.51 5.255 3071.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Dual specificity protein kinase CLK2 EC50 = 1.0 nM 9.0 Inhibition of recombinant CLK2 (unknown origin) using Ser/Thr 6 peptide as subst... -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A EC50 = 2.0 nM 8.7 Inhibition of recombinant DYRK1A (unknown origin) using Ser/Thr 18 peptide as su... -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A EC50 = 2.0 nM 8.7 Kinase Assay: The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyt... -
Dual specificity protein kinase CLK3 EC50 = 13.0 nM 7.89 Inhibition of recombinant CLK3 (unknown origin) using Ser/Thr 18 peptide as subs... -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A EC50 = 23.0 nM 7.64 Kinase Assay: The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyt... -
Unchecked EC50 = 34.8 nM 7.46 Effect on Wnt signaling pathway in human SW480 cells harbouring TCF/LEF lucifera... -
Unchecked EC50 = 1432.0 nM 5.84 Inhibition of IL1-beta induced MMP3 expression levels in human chondrocytes asse... -
Glycogen synthase kinase-3 beta EC50 = 3071.0 nM 5.51 Kinase Assay: Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are ... -
Glycogen synthase kinase-3 beta EC50 = 9990.0 nM 5.0 Kinase Assay: Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are ... -

Data from ChEMBL 36 via Core Engine