Assay Detail
Functional
CHEMBL4768292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Jurkat cells incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.82 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1331211 | — | — | 1 | 5.01 |
| CHEMBL4782019 | — | — | 1 | 4.88 |
| CHEMBL4794447 | — | — | 1 | 4.82 |
| CHEMBL4789391 | — | — | 1 | 4.78 |
| CHEMBL4788226 | — | — | 1 | 4.76 |
| CHEMBL4794595 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1331211 | — | IC50 | = | 9790.0 | nM | 5.01 |
| CHEMBL4782019 | — | IC50 | = | 13040.0 | nM | 4.88 |
| CHEMBL4794447 | — | IC50 | = | 15050.0 | nM | 4.82 |
| CHEMBL4789391 | — | IC50 | = | 16460.0 | nM | 4.78 |
| CHEMBL4788226 | — | IC50 | = | 17240.0 | nM | 4.76 |
| CHEMBL4794595 | — | IC50 | = | 21190.0 | nM | 4.67 |