Assay Detail
Binding
CHEMBL4769735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]paroxetine from human SERT expressed in human HEK293 cells incubated for 30 mins by liquid scintillation counting analysis
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.50 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 8.52 |
| CHEMBL4777782 | — | — | 1 | 5.72 |
| CHEMBL4795221 | — | — | 1 | 5.04 |
| CHEMBL4798858 | — | — | 1 | 4.16 |
| CHEMBL4776389 | — | — | 1 | 4.08 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
| CHEMBL4784248 | — | — | 1 | - |
| CHEMBL4786060 | — | — | 1 | - |
| CHEMBL4782029 | — | — | 1 | - |
| CHEMBL4800092 | — | — | 1 | - |
| CHEMBL4796328 | — | — | 1 | - |
| CHEMBL4797232 | — | — | 1 | - |
| CHEMBL4790454 | — | — | 1 | - |
| CHEMBL4780578 | — | — | 1 | - |
| CHEMBL4798408 | — | — | 1 | - |
| CHEMBL4792068 | — | — | 1 | - |
| CHEMBL4786386 | — | — | 1 | - |
| CHEMBL4783315 | — | — | 1 | - |
| CHEMBL4785452 | — | — | 1 | - |
| CHEMBL4799265 | — | — | 1 | - |
| CHEMBL4780560 | — | — | 1 | - |
| CHEMBL4792702 | — | — | 1 | - |
| CHEMBL4788937 | — | — | 1 | - |
| CHEMBL4785035 | — | — | 1 | - |
| CHEMBL4786778 | — | — | 1 | - |
| CHEMBL4796660 | — | — | 1 | - |
| CHEMBL4798281 | — | — | 1 | - |
| CHEMBL4786300 | — | — | 1 | - |
| CHEMBL4778249 | — | — | 1 | - |
| CHEMBL4781245 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4777782 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4795221 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4798858 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL4776389 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL4782029 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL4793718 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4800092 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL4796328 | — | IC50 | = | 546000.0 | nM | - |
| CHEMBL4797232 | — | IC50 | = | 320000.0 | nM | - |
| CHEMBL4790454 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4780578 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4798408 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4792068 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4786386 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4784248 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4782256 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4800589 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4782574 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4789608 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4786060 | — | IC50 | = | 212000.0 | nM | - |
| CHEMBL502 | DONEPEZIL | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4783315 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4785452 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4799265 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4780560 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4792702 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4788937 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4785035 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4786778 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4796660 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4798281 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4786300 | — | IC50 | = | 181000.0 | nM | - |
| CHEMBL4778249 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4781245 | — | IC50 | = | 149000.0 | nM | - |