Assay Detail
Functional
CHEMBL4770228
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Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.53 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784348 | — | — | 1 | 9.55 |
| CHEMBL4795215 | — | — | 1 | 9.48 |
| CHEMBL1823159 | — | — | 1 | 9.47 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.10 |
| CHEMBL4786045 | — | — | 1 | 8.57 |
| CHEMBL4782713 | — | — | 1 | 8.55 |
| CHEMBL522420 | — | — | 1 | 8.51 |
| CHEMBL4786603 | — | — | 1 | 7.57 |
| CHEMBL4795928 | — | — | 1 | 7.54 |
| CHEMBL4776587 | — | — | 1 | 6.52 |
| CHEMBL4798895 | — | — | 1 | 6.52 |
| CHEMBL4791244 | — | — | 1 | 6.48 |
| CHEMBL4795914 | — | — | 1 | 6.42 |
| CHEMBL4794470 | — | — | 1 | 6.41 |
| CHEMBL4790019 | — | — | 1 | 6.40 |
| CHEMBL4794695 | — | — | 1 | 5.56 |
| CHEMBL4798591 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784348 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL4795215 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL1823159 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4786045 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4782713 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL522420 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4786603 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL4795928 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL4776587 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL4798895 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL4791244 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL4795914 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL4794470 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4790019 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL4794695 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL4798591 | — | IC50 | = | 4390.0 | nM | 5.36 |