Assay Detail
Functional
CHEMBL4773367
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Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay
10
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EA.hy 926 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.70 | 5.61 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223360 | LINIFANIB | 3.0 | 1 | 5.61 |
| CHEMBL4780189 | — | — | 2 | 4.48 |
| CHEMBL4794619 | — | — | 2 | 4.41 |
| CHEMBL3633296 | — | — | 1 | 4.29 |
| CHEMBL4789418 | — | — | 1 | - |
| CHEMBL4792511 | — | — | 1 | - |
| CHEMBL4792399 | — | — | 1 | - |
| CHEMBL4791334 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223360 | LINIFANIB | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4780189 | — | IC50 | = | 32793.0 | nM | 4.48 |
| CHEMBL4794619 | — | IC50 | = | 38650.0 | nM | 4.41 |
| CHEMBL3633296 | — | IC50 | = | 51554.0 | nM | 4.29 |
| CHEMBL4789418 | — | IC50 | - | — | - | |
| CHEMBL4794619 | — | Activity | - | — | - | |
| CHEMBL4792511 | — | IC50 | = | 133248.0 | nM | - |
| CHEMBL4792399 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4780189 | — | Activity | - | — | - | |
| CHEMBL4791334 | — | IC50 | > | 100000.0 | nM | - |