Assay Detail
Functional
CHEMBL4808314
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human TOV112D cells harbouring p53 R175H mutant incubated for 3 days by MTS assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TOV112D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 7.54 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223250 | — | — | 1 | 9.00 |
| CHEMBL4868447 | — | — | 1 | 8.40 |
| CHEMBL1976486 | — | — | 1 | 8.30 |
| CHEMBL386103 | — | — | 1 | 8.22 |
| CHEMBL4871631 | — | — | 1 | 8.10 |
| CHEMBL4866045 | — | — | 1 | 7.96 |
| CHEMBL4863902 | — | — | 1 | 7.66 |
| CHEMBL4869989 | — | — | 1 | 7.38 |
| CHEMBL4864135 | — | — | 1 | 7.32 |
| CHEMBL4867513 | — | — | 1 | 7.29 |
| CHEMBL4877956 | — | — | 1 | 7.28 |
| CHEMBL4789856 | — | — | 1 | 7.26 |
| CHEMBL4859786 | — | — | 1 | 7.03 |
| CHEMBL4855830 | — | — | 1 | 6.88 |
| CHEMBL4865785 | — | — | 1 | 6.85 |
| CHEMBL4869138 | — | — | 1 | 6.82 |
| CHEMBL4861093 | — | — | 1 | 6.35 |
| CHEMBL4866575 | — | — | 1 | - |
| CHEMBL4878692 | — | — | 1 | - |
| CHEMBL4868490 | — | — | 1 | - |
| CHEMBL4871648 | — | — | 1 | - |
| CHEMBL4848323 | — | — | 1 | - |
| CHEMBL4861614 | — | — | 1 | - |
| CHEMBL4854242 | — | — | 1 | - |
| CHEMBL4857176 | — | — | 1 | - |
| CHEMBL4873344 | — | — | 1 | - |
| CHEMBL4868681 | — | — | 1 | - |
| CHEMBL1989044 | — | — | 1 | - |
| CHEMBL4848680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223250 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4868447 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1976486 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL386103 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4871631 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4866045 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4863902 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4869989 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4864135 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4867513 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4877956 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4789856 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4859786 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4855830 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4865785 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4869138 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4861093 | — | EC50 | = | 445.0 | nM | 6.35 |
| CHEMBL4866575 | — | EC50 | - | — | - | |
| CHEMBL4878692 | — | EC50 | - | — | - | |
| CHEMBL4868490 | — | EC50 | - | — | - | |
| CHEMBL4871648 | — | EC50 | - | — | - | |
| CHEMBL4848323 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4861614 | — | EC50 | - | — | - | |
| CHEMBL4854242 | — | EC50 | - | — | - | |
| CHEMBL4857176 | — | EC50 | - | — | - | |
| CHEMBL4873344 | — | EC50 | - | — | - | |
| CHEMBL4868681 | — | EC50 | - | — | - | |
| CHEMBL1989044 | — | EC50 | - | — | - | |
| CHEMBL4848680 | — | EC50 | - | — | - |