Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4809424

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human Jurkat cells incubated for 48 hrs by CCK-8 assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Autocuration

Target

Jurkat (CHEMBL397)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of 4-Arylindolines Containing a Thiazole Moiety as Potential Antitumor Agents Inhibiting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction.
Qin M, Meng Y, Yang H, Liu L, Zhang H, Wang S, Liu C, Wu X, Wu D, Tian Y, Hou Y, Zhao Y, Liu Y, Xu C, Wang L.
J Med Chem (2021) 64 : 5519 -5534
PubMed 33938739 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 4.89 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4871378 1 6.05
CHEMBL4863242 1 5.92
CHEMBL4873504 1 5.23
CHEMBL4845971 1 5.12
CHEMBL4865166 1 5.03
CHEMBL4877307 1 5.02
CHEMBL4875099 1 5.02
CHEMBL4871618 1 4.97
CHEMBL4851678 1 4.92
CHEMBL4874789 1 4.89
CHEMBL4858375 1 4.87
CHEMBL4858863 1 4.86
CHEMBL4876230 1 4.84
CHEMBL4877207 1 4.79
CHEMBL4846175 1 4.75
CHEMBL3582252 1 4.74
CHEMBL4851240 1 4.73
CHEMBL4846192 1 4.72
CHEMBL4876140 1 4.69
CHEMBL4855372 1 4.68
CHEMBL4857610 1 4.42
CHEMBL4749782 1 4.41
CHEMBL4865262 1 4.36
CHEMBL4859877 1 4.33
CHEMBL4874277 1 -
CHEMBL4847490 1 -
CHEMBL4853305 1 -
CHEMBL4858084 1 -
CHEMBL4860618 1 -
CHEMBL4866188 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4871378 IC50 = 900.0 nM 6.05
CHEMBL4863242 IC50 = 1200.0 nM 5.92
CHEMBL4873504 IC50 = 5900.0 nM 5.23
CHEMBL4845971 IC50 = 7500.0 nM 5.12
CHEMBL4865166 IC50 = 9300.0 nM 5.03
CHEMBL4877307 IC50 = 9500.0 nM 5.02
CHEMBL4875099 IC50 = 9500.0 nM 5.02
CHEMBL4871618 IC50 = 10800.0 nM 4.97
CHEMBL4851678 IC50 = 12100.0 nM 4.92
CHEMBL4874789 IC50 = 12900.0 nM 4.89
CHEMBL4858375 IC50 = 13400.0 nM 4.87
CHEMBL4858863 IC50 = 13700.0 nM 4.86
CHEMBL4876230 IC50 = 14300.0 nM 4.84
CHEMBL4877207 IC50 = 16300.0 nM 4.79
CHEMBL4846175 IC50 = 18000.0 nM 4.75
CHEMBL3582252 IC50 = 18400.0 nM 4.74
CHEMBL4851240 IC50 = 18600.0 nM 4.73
CHEMBL4846192 IC50 = 19200.0 nM 4.72
CHEMBL4876140 IC50 = 20400.0 nM 4.69
CHEMBL4855372 IC50 = 20700.0 nM 4.68
CHEMBL4857610 IC50 = 37800.0 nM 4.42
CHEMBL4749782 IC50 = 38600.0 nM 4.41
CHEMBL4865262 IC50 = 43700.0 nM 4.36
CHEMBL4859877 IC50 = 46200.0 nM 4.33
CHEMBL4861627 IC50 - -
CHEMBL4864895 IC50 - -
CHEMBL4877245 IC50 - -
CHEMBL4876786 IC50 - -
CHEMBL4864208 IC50 - -
CHEMBL4855102 IC50 > 50000.0 nM -
CHEMBL4857549 IC50 - -
CHEMBL4850947 IC50 > 50000.0 nM -
CHEMBL4866188 IC50 - -
CHEMBL4860618 IC50 - -
CHEMBL4858084 IC50 - -
CHEMBL4853305 IC50 - -
CHEMBL4847490 IC50 > 50000.0 nM -
CHEMBL4874277 IC50 > 50000.0 nM -