Assay Detail
Functional
CHEMBL4809637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.91 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.22 |
| CHEMBL4858563 | — | — | 1 | 5.35 |
| CHEMBL4874240 | — | — | 1 | 4.97 |
| CHEMBL4877553 | — | — | 1 | 4.97 |
| CHEMBL4848045 | — | — | 1 | 4.95 |
| CHEMBL4873186 | — | — | 1 | 4.93 |
| CHEMBL4846202 | — | — | 1 | 4.89 |
| CHEMBL4862551 | — | — | 1 | 4.89 |
| CHEMBL4849379 | — | — | 1 | 4.72 |
| CHEMBL4850383 | — | — | 1 | 4.66 |
| CHEMBL4865800 | — | — | 1 | 4.65 |
| CHEMBL4853311 | — | — | 1 | 4.63 |
| CHEMBL4875946 | — | — | 1 | 4.50 |
| CHEMBL4857534 | — | — | 1 | 4.48 |
| CHEMBL4873691 | — | — | 1 | 4.41 |
| CHEMBL4858778 | — | — | 1 | 4.34 |
| CHEMBL4867047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4858563 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4874240 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4877553 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4848045 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4873186 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4846202 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4862551 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4849379 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4850383 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL4865800 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL4853311 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4875946 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL4857534 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL4873691 | — | IC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL4858778 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4867047 | — | IC50 | > | 50000.0 | nM | - |