Assay Detail
ADMET
CHEMBL4810140
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Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in baculovirus infected Sf21insect cells using biotin-labeled EQEDEPEGDYFEWLE peptide as substrate incubated for 20 mins in presence of ATP by plate reader assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.69 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870179 | — | — | 1 | 7.62 |
| CHEMBL4862823 | — | — | 1 | 7.40 |
| CHEMBL4863224 | — | — | 1 | 7.04 |
| CHEMBL4847441 | — | — | 1 | 6.88 |
| CHEMBL4863146 | — | — | 1 | 6.79 |
| CHEMBL4856613 | — | — | 1 | 6.34 |
| CHEMBL4861534 | — | — | 1 | 5.78 |
| CHEMBL4862283 | — | — | 1 | 5.69 |
| CHEMBL4868291 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870179 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4862823 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4863224 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4847441 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL4863146 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4856613 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL4861534 | — | IC50 | = | 1677.0 | nM | 5.78 |
| CHEMBL4862283 | — | IC50 | = | 2058.0 | nM | 5.69 |
| CHEMBL4868291 | — | IC50 | > | 2000.0 | nM | - |