Compound Detail
CHEMBL4861534
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Basic Information
| ChEMBL ID | CHEMBL4861534 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RIKRPKXSOVGMHC-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
282.3
MW (Da)
3.37
ALogP
3
HBA
1
HBD
47.1
PSA (Ų)
0.78
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.08 | 7.08 | 83.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.78 | 5.78 | 1677.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 83.0 | nM | 7.08 | Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrat... | 34269576 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1677.0 | nM | 5.78 | Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in bacul... | 34269576 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34269576 | 10.1021/acs.jmedchem.1c00713 | Fibroblast growth factor receptor 1 | 1 |
| 34269576 | 10.1021/acs.jmedchem.1c00713 | Vascular endothelial growth factor receptor 2 | 1 |
| 34269576 | 10.1021/acs.jmedchem.1c00713 | Tyrosine-protein kinase JAK2 | 1 |
Data from ChEMBL 36 via Core Engine