Assay Detail
Binding
CHEMBL4810137
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Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.36 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870179 | — | — | 1 | 9.92 |
| CHEMBL4862823 | — | — | 1 | 9.77 |
| CHEMBL4846809 | — | — | 1 | 9.10 |
| CHEMBL4863146 | — | — | 1 | 8.96 |
| CHEMBL4863224 | — | — | 1 | 8.96 |
| CHEMBL4851637 | — | — | 1 | 8.82 |
| CHEMBL4847441 | — | — | 1 | 8.72 |
| CHEMBL4874869 | — | — | 1 | 8.36 |
| CHEMBL4862283 | — | — | 1 | 8.22 |
| CHEMBL4856613 | — | — | 1 | 8.12 |
| CHEMBL4871046 | — | — | 1 | 8.04 |
| CHEMBL4858423 | — | — | 1 | 8.01 |
| CHEMBL4848530 | — | — | 1 | 7.70 |
| CHEMBL4873003 | — | — | 1 | 7.68 |
| CHEMBL4866178 | — | — | 1 | 7.57 |
| CHEMBL4868291 | — | — | 1 | 7.09 |
| CHEMBL4861534 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870179 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4862823 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL4846809 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL4863146 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4863224 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4851637 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4847441 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4874869 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4862283 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4856613 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4871046 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4858423 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4848530 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4873003 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4866178 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4868291 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4861534 | — | IC50 | = | 83.0 | nM | 7.08 |