Compound Detail
CHEMBL4862283
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Basic Information
| ChEMBL ID | CHEMBL4862283 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PCOYIUXQMCLNDD-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
484.6
MW (Da)
4.81
ALogP
9
HBA
1
HBD
108.5
PSA (Ų)
0.37
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.69 | 5.69 | 2058.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrat... | 34269576 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 2058.0 | nM | 5.69 | Inhibition of human recombinant N-terminal His6-tagged VEGFR2 expressed in bacul... | 34269576 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34269576 | 10.1021/acs.jmedchem.1c00713 | Fibroblast growth factor receptor 1 | 1 |
| 34269576 | 10.1021/acs.jmedchem.1c00713 | Vascular endothelial growth factor receptor 2 | 1 |
| 34269576 | 10.1021/acs.jmedchem.1c00713 | Tyrosine-protein kinase JAK2 | 1 |
Data from ChEMBL 36 via Core Engine