Assay Detail
Functional
CHEMBL4810405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Chemo-protective activity in C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as reduction in 18F-FDG uptake in ileum at 300 mg/kg, po incorporated into chow diet administered daily for 2 weeks and measured after 14 days by ex vivo PET imaging analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.15 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4868446 | — | — | 1 | 5.38 |
| CHEMBL4862802 | — | — | 1 | 5.36 |
| CHEMBL4870569 | — | — | 1 | 5.26 |
| CHEMBL4865464 | — | — | 1 | 4.89 |
| CHEMBL4857474 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4868446 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4862802 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4870569 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4865464 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4857474 | — | IC50 | = | 14000.0 | nM | 4.85 |