Assay Detail
Functional
CHEMBL4810682
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Anti-cryptosporidial activity against Cryptosporidium parvum infected in HCT-8 cells pre-infected for 3 hrs followed by compound treatment and measured after 45 hrs by fluorescence microscopy analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cryptosporidium parvum |
| Cell Type | HCT-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 5.31 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850904 | — | — | 1 | 6.77 |
| CHEMBL4868942 | — | — | 1 | 6.26 |
| CHEMBL4853022 | — | — | 1 | 6.21 |
| CHEMBL4856541 | — | — | 1 | 6.18 |
| CHEMBL4863029 | — | — | 1 | 6.07 |
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 1 | 5.70 |
| CHEMBL582486 | — | — | 1 | 5.68 |
| CHEMBL4872325 | — | — | 1 | 5.66 |
| CHEMBL4866251 | — | — | 1 | 5.64 |
| CHEMBL4866023 | — | — | 1 | 5.60 |
| CHEMBL4863901 | — | — | 1 | 5.46 |
| CHEMBL4865724 | — | — | 1 | 5.16 |
| CHEMBL4859288 | — | — | 1 | 5.15 |
| CHEMBL4849356 | — | — | 1 | 5.07 |
| CHEMBL4874319 | — | — | 1 | 4.96 |
| CHEMBL4861032 | — | — | 1 | 4.96 |
| CHEMBL4861870 | — | — | 1 | 4.92 |
| CHEMBL4866690 | — | — | 1 | 4.92 |
| CHEMBL4853737 | — | — | 1 | 4.85 |
| CHEMBL4859801 | — | — | 1 | 4.80 |
| CHEMBL4871201 | — | — | 1 | 4.77 |
| CHEMBL4849755 | — | — | 1 | 4.77 |
| CHEMBL4857487 | — | — | 1 | 4.75 |
| CHEMBL4871763 | — | — | 1 | 4.66 |
| CHEMBL4867564 | — | — | 1 | 4.54 |
| CHEMBL4849696 | — | — | 1 | 4.50 |
| CHEMBL4855320 | — | — | 1 | - |
| CHEMBL4855053 | — | — | 1 | - |
| CHEMBL4869919 | — | — | 1 | - |
| CHEMBL4863982 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850904 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4868942 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4853022 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4856541 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4863029 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1401 | NITAZOXANIDE | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL582486 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4872325 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4866251 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4866023 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4863901 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4865724 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4859288 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4849356 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4874319 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4861032 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4861870 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4866690 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4853737 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4859801 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4871201 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4849755 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4857487 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4871763 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4867564 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4849696 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4855320 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4855053 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4869919 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4863982 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4855791 | — | EC50 | > | 25000.0 | nM | - |