Assay Detail
ADMET
CHEMBL4812673
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Inhibition of CYP2C9 (unknown origin) by UPLC-MS analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.24 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850116 | — | — | 1 | 5.77 |
| CHEMBL4876457 | — | — | 1 | 5.54 |
| CHEMBL4848632 | — | — | 1 | 4.92 |
| CHEMBL4850393 | — | — | 1 | 4.72 |
| CHEMBL4851471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850116 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4876457 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4848632 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4850393 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4851471 | — | IC50 | < | 250.0 | nM | - |