Assay Detail
Functional
CHEMBL4813204
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Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 72 hrs
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New camptothecin derivatives for generalized oncological chemotherapy: Synthesis, stereochemistry and biology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.06 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.70 |
| CHEMBL4871226 | — | — | 1 | 8.15 |
| CHEMBL4865556 | — | — | 1 | 8.05 |
| CHEMBL4848652 | — | — | 1 | 7.96 |
| CHEMBL4851112 | — | — | 1 | 6.95 |
| CHEMBL4859129 | — | — | 1 | 6.48 |
| CHEMBL4854308 | — | — | 1 | 6.14 |
| CHEMBL4870090 | — | — | 1 | 5.72 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4871226 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4865556 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4848652 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4851112 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4859129 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL4854308 | — | IC50 | = | 722.0 | nM | 6.14 |
| CHEMBL4870090 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 4240.0 | nM | 5.37 |