Assay Detail
Binding
CHEMBL4814797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO-K1 cells by radioligand binding assay
13
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isolation and Pharmacological Characterization of Six Opioidergic <i>Picralima nitida</i> Alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.45 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 2 | 9.50 |
| CHEMBL4871880 | — | — | 2 | 6.52 |
| CHEMBL4856018 | — | — | 2 | 6.50 |
| CHEMBL4846243 | — | — | 2 | 6.23 |
| CHEMBL508955 | AKUAMMICINE | — | 2 | 5.50 |
| CHEMBL4874877 | — | — | 2 | 4.51 |
| CHEMBL4852987 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL38874 | DAMGO | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL4871880 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL4856018 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL4871880 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL4856018 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL4846243 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL4846243 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL508955 | AKUAMMICINE | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL508955 | AKUAMMICINE | Ki | = | 3310.0 | nM | 5.48 |
| CHEMBL4874877 | — | Ki | = | 30700.0 | nM | 4.51 |
| CHEMBL4874877 | — | Ki | = | 31622.78 | nM | 4.50 |
| CHEMBL4852987 | — | Ki | = | 132000.0 | nM | - |