Assay Detail
Functional
CHEMBL4815477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at guinea pig right atrium histamine H2 receptor assessed as increase in heart rate incubated for 30 mins in presence of cimetidine
29
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Right cardiac atrium |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H<sub>2</sub>R and D<sub>3</sub>R.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.41 | 8.24 |
| pEC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860528 | — | — | 1 | 8.24 |
| CHEMBL4856059 | — | — | 1 | 8.12 |
| CHEMBL4846380 | — | — | 1 | 8.01 |
| CHEMBL4861704 | — | — | 1 | 8.00 |
| CHEMBL4870510 | — | — | 1 | 7.97 |
| CHEMBL4865965 | — | — | 1 | 7.93 |
| CHEMBL4864852 | — | — | 1 | 7.91 |
| CHEMBL4869389 | — | — | 1 | 7.89 |
| CHEMBL4853668 | — | — | 1 | 7.80 |
| CHEMBL4869194 | — | — | 1 | 7.65 |
| CHEMBL4867962 | — | — | 1 | 7.63 |
| CHEMBL4848697 | — | — | 1 | 7.63 |
| CHEMBL4863347 | — | — | 1 | 7.61 |
| CHEMBL4852212 | — | — | 1 | 7.59 |
| CHEMBL4875600 | — | — | 1 | 7.58 |
| CHEMBL4858849 | — | — | 1 | 7.46 |
| CHEMBL4848026 | — | — | 1 | 7.42 |
| CHEMBL4876025 | — | — | 1 | 7.40 |
| CHEMBL4850448 | — | — | 1 | 7.32 |
| CHEMBL4876267 | — | — | 1 | 7.26 |
| CHEMBL4856602 | — | — | 1 | 7.18 |
| CHEMBL4853772 | — | — | 1 | 7.05 |
| CHEMBL4845733 | — | — | 1 | 6.83 |
| CHEMBL4866734 | — | — | 1 | 6.76 |
| CHEMBL4854278 | — | — | 1 | 6.65 |
| CHEMBL4850490 | — | — | 1 | 6.31 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 6.16 |
| CHEMBL4863523 | — | — | 1 | 6.14 |
| CHEMBL4856200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860528 | — | EC50 | = | 5.754 | nM | 8.24 |
| CHEMBL4856059 | — | EC50 | = | 7.586 | nM | 8.12 |
| CHEMBL4846380 | — | EC50 | = | 9.772 | nM | 8.01 |
| CHEMBL4861704 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4870510 | — | EC50 | = | 10.72 | nM | 7.97 |
| CHEMBL4865965 | — | EC50 | = | 11.75 | nM | 7.93 |
| CHEMBL4864852 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL4869389 | — | EC50 | = | 12.88 | nM | 7.89 |
| CHEMBL4853668 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL4869194 | — | EC50 | = | 22.39 | nM | 7.65 |
| CHEMBL4867962 | — | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL4848697 | — | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL4863347 | — | EC50 | = | 24.55 | nM | 7.61 |
| CHEMBL4852212 | — | EC50 | = | 25.7 | nM | 7.59 |
| CHEMBL4875600 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL4858849 | — | EC50 | = | 34.67 | nM | 7.46 |
| CHEMBL4848026 | — | EC50 | = | 38.02 | nM | 7.42 |
| CHEMBL4876025 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4850448 | — | EC50 | = | 47.86 | nM | 7.32 |
| CHEMBL4876267 | — | EC50 | = | 54.95 | nM | 7.26 |
| CHEMBL4856602 | — | EC50 | = | 66.07 | nM | 7.18 |
| CHEMBL4853772 | — | EC50 | = | 89.13 | nM | 7.05 |
| CHEMBL4845733 | — | EC50 | = | 147.91 | nM | 6.83 |
| CHEMBL4866734 | — | EC50 | = | 173.78 | nM | 6.76 |
| CHEMBL4854278 | — | EC50 | = | 223.87 | nM | 6.65 |
| CHEMBL4850490 | — | EC50 | = | 489.78 | nM | 6.31 |
| CHEMBL90 | HISTAMINE | EC50 | = | 691.83 | nM | 6.16 |
| CHEMBL4863523 | — | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL4856200 | — | pEC50 | - | — | - |