Compound Detail
CHEMBL4866734
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Basic Information
| ChEMBL ID | CHEMBL4866734 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LTOCIZKLCRDDHX-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
436.6
MW (Da)
3.41
ALogP
4
HBA
4
HBD
118.4
PSA (Ų)
0.25
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 7.06
EC50 1 meas. best 6.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H2 receptor CHEMBL1941 | Ki | 7.06 | 7.06 | 87.1 | 1 |
| Histamine H2 receptor CHEMBL2882 | EC50 | 6.76 | 6.76 | 173.8 | 1 |
| Histamine H4 receptor CHEMBL3759 | Ki | 5.31 | 5.31 | 4897.8 | 1 |
| Histamine H1 receptor CHEMBL231 | Ki | 5.28 | 5.28 | 5248.1 | 1 |
| Histamine H3 receptor CHEMBL264 | Ki | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H2 receptor | Ki | = | 87.1 | nM | 7.06 | Displacement of [3H]UR-DE257 from human histamine H2 receptor expressed in sf9 i... | 33548637 |
| Histamine H2 receptor | EC50 | = | 173.78 | nM | 6.76 | Agonist activity at guinea pig right atrium histamine H2 receptor assessed as in... | 33548637 |
| Histamine H4 receptor | Ki | = | 4897.79 | nM | 5.31 | Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 ... | 33548637 |
| Histamine H1 receptor | Ki | = | 5248.07 | nM | 5.28 | Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9... | 33548637 |
| Histamine H3 receptor | Ki | = | 10000.0 | nM | 5.0 | Displacement of [3H]UR-P129 from human histamine H3 receptor expressed in sf9 in... | 33548637 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33548637 | 10.1016/j.ejmech.2021.113190 | Histamine H2 receptor | 3 |
| 33548637 | 10.1016/j.ejmech.2021.113190 | Unchecked | 3 |
| 33548637 | 10.1016/j.ejmech.2021.113190 | Histamine H1 receptor | 1 |
| 33548637 | 10.1016/j.ejmech.2021.113190 | Histamine H3 receptor | 1 |
| 33548637 | 10.1016/j.ejmech.2021.113190 | Histamine H4 receptor | 1 |
Data from ChEMBL 36 via Core Engine