Assay Detail
Binding
CHEMBL4815626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-citalopram from human SERT receptor incubated for 1 hr by liquid scintillation counting method
14
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.00 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859722 | — | — | 2 | 6.61 |
| CHEMBL4866053 | — | — | 1 | 6.41 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 5.97 |
| CHEMBL4857597 | — | — | 2 | 5.96 |
| CHEMBL4857665 | — | — | 2 | 5.72 |
| CHEMBL4865591 | — | — | 2 | 5.58 |
| CHEMBL4846823 | — | — | 2 | - |
| CHEMBL4871868 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859722 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL4859722 | — | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL4866053 | — | Ki | = | 392.0 | nM | 6.41 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL4857597 | — | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL4857597 | — | Ki | = | 1143.0 | nM | 5.94 |
| CHEMBL4857665 | — | Ki | = | 1905.46 | nM | 5.72 |
| CHEMBL4857665 | — | Ki | = | 2184.0 | nM | 5.66 |
| CHEMBL4865591 | — | Ki | = | 2630.27 | nM | 5.58 |
| CHEMBL4865591 | — | Ki | = | 3064.6 | nM | 5.51 |
| CHEMBL4846823 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4871868 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4846823 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4871868 | — | Ki | > | 10000.0 | nM | - |