Assay Detail
Functional
CHEMBL4816282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at muscarinic M3 receptor (unknown origin) expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.18 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4748915 | — | — | 1 | 6.19 |
| CHEMBL845 | N-DESMETHYLCLOZAPINE | — | 1 | 6.17 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | - |
| CHEMBL4852403 | — | — | 1 | - |
| CHEMBL4873426 | — | — | 1 | - |
| CHEMBL4849385 | — | — | 1 | - |
| CHEMBL4856628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4748915 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL845 | N-DESMETHYLCLOZAPINE | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL42 | CLOZAPINE | EC50 | > | 10000.0 | nM | - |
| CHEMBL4852403 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4873426 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4849385 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4856628 | — | EC50 | > | 10000.0 | nM | - |