Assay Detail
Binding
CHEMBL4817145
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Inhibition of bacterial Beta-lactamase AmpC (20 - 377) (unknown origin) expressed in Escherichia coli Transetta (DE3)
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.06 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 7.62 |
| CHEMBL4875860 | — | — | 1 | 5.44 |
| CHEMBL4858119 | — | — | 1 | 5.44 |
| CHEMBL4879305 | — | — | 1 | 5.28 |
| CHEMBL4861004 | — | — | 1 | 5.25 |
| CHEMBL4861951 | — | — | 1 | 5.14 |
| CHEMBL4875926 | — | — | 1 | 5.08 |
| CHEMBL4871947 | — | — | 1 | 5.07 |
| CHEMBL4878058 | — | — | 1 | 4.97 |
| CHEMBL4866950 | — | — | 1 | 4.94 |
| CHEMBL4875825 | — | — | 1 | 4.86 |
| CHEMBL4856812 | — | — | 1 | 4.82 |
| CHEMBL4849046 | — | — | 1 | 4.82 |
| CHEMBL4878895 | — | — | 1 | 4.73 |
| CHEMBL4855048 | — | — | 1 | 4.64 |
| CHEMBL4864629 | — | — | 1 | 4.59 |
| CHEMBL4864824 | — | — | 1 | 4.53 |
| CHEMBL4861373 | — | — | 1 | 4.49 |
| CHEMBL4875141 | — | — | 1 | 4.41 |
| CHEMBL4864134 | — | — | 1 | - |
| CHEMBL4872823 | — | — | 1 | - |
| CHEMBL4851510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1689063 | AVIBACTAM | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4875860 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL4858119 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4879305 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4861004 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL4861951 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL4875926 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL4871947 | — | IC50 | = | 8520.0 | nM | 5.07 |
| CHEMBL4878058 | — | IC50 | = | 10750.0 | nM | 4.97 |
| CHEMBL4866950 | — | IC50 | = | 11390.0 | nM | 4.94 |
| CHEMBL4875825 | — | IC50 | = | 13880.0 | nM | 4.86 |
| CHEMBL4856812 | — | IC50 | = | 15090.0 | nM | 4.82 |
| CHEMBL4849046 | — | IC50 | = | 15270.0 | nM | 4.82 |
| CHEMBL4878895 | — | IC50 | = | 18740.0 | nM | 4.73 |
| CHEMBL4855048 | — | IC50 | = | 22690.0 | nM | 4.64 |
| CHEMBL4864629 | — | IC50 | = | 25870.0 | nM | 4.59 |
| CHEMBL4864824 | — | IC50 | = | 29220.0 | nM | 4.53 |
| CHEMBL4861373 | — | IC50 | = | 32220.0 | nM | 4.49 |
| CHEMBL4875141 | — | IC50 | = | 39290.0 | nM | 4.41 |
| CHEMBL4864134 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4872823 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4851510 | — | IC50 | > | 100000.0 | nM | - |