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Compound Detail

CHEMBL4855048

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CN(C)c1ccc(C2OB(O)c3ccc(Cl)cc32)cc1

Basic Information

ChEMBL ID CHEMBL4855048
Phase Preclinical
Structure Type MOL
InChI Key BBNXKBWPPCQJID-UHFFFAOYSA-N
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

287.6
MW (Da)

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H15BClNO2
MW 287.56

Activity Summary

IC50 6 meas. best 7.07

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 7.07 5.56 86.0 5
Beta-lactamase TEM
CHEMBL2364670
IC50 5.81 5.81 1540.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33744439 10.1016/j.bmcl.2021.127956 Unchecked 6
33744439 10.1016/j.bmcl.2021.127956 Escherichia coli 4
33744439 10.1016/j.bmcl.2021.127956 Klebsiella pneumoniae 2
33744439 10.1016/j.bmcl.2021.127956 Beta-lactamase TEM 1
33744439 10.1016/j.bmcl.2021.127956 HEK-293T 1

Data from ChEMBL 36 via Core Engine