Assay Detail
Binding
CHEMBL4817144
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Inhibition of bacterial Beta-lactamase TEM-1 (24 - 286) (unknown origin) expressed in Escherichia coli Transetta (DE3)
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.48 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 8.72 |
| CHEMBL4875926 | — | — | 1 | 6.14 |
| CHEMBL4879305 | — | — | 1 | 5.94 |
| CHEMBL4866950 | — | — | 1 | 5.81 |
| CHEMBL4855048 | — | — | 1 | 5.81 |
| CHEMBL4875825 | — | — | 1 | 5.50 |
| CHEMBL4858119 | — | — | 1 | 5.36 |
| CHEMBL4864824 | — | — | 1 | 5.35 |
| CHEMBL4875141 | — | — | 1 | 5.25 |
| CHEMBL4878895 | — | — | 1 | 5.16 |
| CHEMBL4856812 | — | — | 1 | 4.68 |
| CHEMBL4861373 | — | — | 1 | 4.48 |
| CHEMBL4849046 | — | — | 1 | 4.42 |
| CHEMBL4861951 | — | — | 1 | 4.05 |
| CHEMBL4851510 | — | — | 1 | - |
| CHEMBL4878058 | — | — | 1 | - |
| CHEMBL4872823 | — | — | 1 | - |
| CHEMBL4864134 | — | — | 1 | - |
| CHEMBL4871947 | — | — | 1 | - |
| CHEMBL4864629 | — | — | 1 | - |
| CHEMBL4861004 | — | — | 1 | - |
| CHEMBL4875860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1689063 | AVIBACTAM | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4875926 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4879305 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4866950 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4855048 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4875825 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4858119 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL4864824 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL4875141 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL4878895 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL4856812 | — | IC50 | = | 20730.0 | nM | 4.68 |
| CHEMBL4861373 | — | IC50 | = | 32960.0 | nM | 4.48 |
| CHEMBL4849046 | — | IC50 | = | 37870.0 | nM | 4.42 |
| CHEMBL4861951 | — | IC50 | = | 88830.0 | nM | 4.05 |
| CHEMBL4851510 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4878058 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4872823 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4864134 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4871947 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4864629 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4861004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4875860 | — | IC50 | > | 100000.0 | nM | - |