Assay Detail
Binding
CHEMBL4817848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human brain PRL-3 (1 to 168 residues) expressed in Escherichia coli BL21(DE3) cells using DiFMUP as substrate incubated for 1 hr by fluorimetric assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein tyrosine phosphatase type IVA 3 (CHEMBL4162) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The dual inhibition against the activity and expression of tyrosine phosphatase PRL-3 from a rhodanine derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.46 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377324 | GINKGETIN | — | 1 | 4.59 |
| CHEMBL208908 | SCIADOPITISIN | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377324 | GINKGETIN | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL208908 | SCIADOPITISIN | IC50 | = | 46200.0 | nM | 4.33 |