Assay Detail
Binding
CHEMBL4817899
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Inhibition of MAGL (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.72 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570812 | — | — | 1 | 7.70 |
| CHEMBL1356127 | — | — | 1 | 5.55 |
| CHEMBL1364928 | — | — | 1 | 5.54 |
| CHEMBL1396461 | — | — | 1 | 5.24 |
| CHEMBL1329986 | — | — | 1 | 5.18 |
| CHEMBL4846054 | — | — | 1 | 5.08 |
| CHEMBL1610344 | — | — | 1 | - |
| CHEMBL4871817 | — | — | 1 | - |
| CHEMBL4850461 | — | — | 1 | - |
| CHEMBL4878686 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570812 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1356127 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL1364928 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL1396461 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1329986 | — | IC50 | = | 6580.0 | nM | 5.18 |
| CHEMBL4846054 | — | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL1610344 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL4871817 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL4850461 | — | IC50 | > | 33300.0 | nM | - |
| CHEMBL4878686 | — | IC50 | > | 33300.0 | nM | - |