Compound Detail
CHEMBL1364928
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Basic Information
| ChEMBL ID | CHEMBL1364928 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HGNATFYYPPTOPR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
434.6
MW (Da)
4.49
ALogP
5
HBA
0
HBD
39.7
PSA (Ų)
0.61
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monoglyceride lipase CHEMBL4191 | IC50 | 5.54 | 5.54 | 2870.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monoglyceride lipase | IC50 | = | 2870.0 | nM | 5.54 | Inhibition of MAGL (unknown origin) | 33766770 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33766770 | 10.1016/j.bmcl.2021.127986 | Monoglyceride lipase | 2 |
Data from ChEMBL 36 via Core Engine