Assay Detail
ADMET
CHEMBL4818547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C9 in human liver microsomes assessed as reduction in 4'-hydroxy diclofenac level using diclofenac as substrate incubated for 10 mins by LC-MS/MS analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.20 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4858081 | — | — | 1 | 5.80 |
| CHEMBL4861270 | — | — | 1 | 5.60 |
| CHEMBL4872186 | — | — | 1 | 5.54 |
| CHEMBL4874919 | — | — | 1 | 5.47 |
| CHEMBL4879154 | — | — | 1 | 4.46 |
| CHEMBL4851511 | — | — | 1 | 4.30 |
| CHEMBL4867665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4858081 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4861270 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4872186 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4874919 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4879154 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4851511 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4867665 | — | IC50 | > | 50000.0 | nM | - |