Assay Detail
Functional
CHEMBL4819527
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Agonist activity at human beta2 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Advances in β<sub>2</sub>-Agonists for Treatment of Chronic Respiratory Diseases and Heart Failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.11 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 9.15 |
| CHEMBL1363 | ARFORMOTEROL | 4.0 | 1 | 8.58 |
| CHEMBL714 | ALBUTEROL | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1263 | SALMETEROL | EC50 | = | 0.71 | nM | 9.15 |
| CHEMBL1363 | ARFORMOTEROL | EC50 | = | 2.63 | nM | 8.58 |
| CHEMBL714 | ALBUTEROL | EC50 | = | 251.0 | nM | 6.60 |