Assay Detail
ADMET
CHEMBL4819835
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Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NCM460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.24 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857769 | — | — | 1 | 5.51 |
| CHEMBL4867199 | — | — | 1 | 5.33 |
| CHEMBL4877623 | — | — | 1 | 5.29 |
| CHEMBL4856163 | — | — | 1 | 5.29 |
| CHEMBL4877512 | — | — | 1 | 5.17 |
| CHEMBL4870520 | — | — | 1 | 5.09 |
| CHEMBL4863228 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857769 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL4867199 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL4877623 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL4856163 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL4877512 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL4870520 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4863228 | — | IC50 | = | 10000.0 | nM | 5.00 |