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Assay Detail

CHEMBL4820034

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at FXR-LBD (unknown origin) assessed by ligand binding ability incubated for 3 hrs in absence of light measured by TR-FRET Coactivator assay
ChEMBL ↗
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bile acid receptor (CHEMBL2047) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist.
Hu L, Ren Q, Deng L, Zhou Z, Cai Z, Wang B, Li Z.
Eur J Med Chem (2021) 211 : 113106 -113106
PubMed 33360559 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 47 6.36 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4863387 — — 1 7.60
CHEMBL318457 — — 1 7.19
CHEMBL4869657 — — 1 7.17
CHEMBL4860451 — — 1 7.01
CHEMBL4865947 — — 1 6.98
CHEMBL4870317 — — 1 6.90
CHEMBL4870713 — — 1 6.87
CHEMBL4853653 — — 1 6.86
CHEMBL4863475 — — 1 6.77
CHEMBL4872750 — — 1 6.72
CHEMBL4858153 — — 1 6.69
CHEMBL4852555 — — 1 6.69
CHEMBL4876494 — — 1 6.67
CHEMBL4875018 — — 1 6.59
CHEMBL4858538 — — 1 6.59
CHEMBL4865925 — — 1 6.58
CHEMBL4866211 — — 1 6.55
CHEMBL4876049 — — 1 6.50
CHEMBL4864546 — — 1 6.50
CHEMBL4863958 — — 1 6.45
CHEMBL4852351 — — 1 6.22
CHEMBL4869052 — — 1 5.99
CHEMBL4855848 — — 1 5.99
CHEMBL4876646 — — 1 5.95
CHEMBL4851956 — — 1 5.93
CHEMBL4846767 — — 1 5.90
CHEMBL4867411 — — 1 5.85
CHEMBL4847135 — — 1 5.77
CHEMBL4873474 — — 1 5.73
CHEMBL4868734 — — 1 5.67

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4863387 — EC50 = 25.0 nM 7.60
CHEMBL318457 — EC50 = 65.0 nM 7.19
CHEMBL4869657 — EC50 = 68.0 nM 7.17
CHEMBL4860451 — EC50 = 97.0 nM 7.01
CHEMBL4865947 — EC50 = 105.0 nM 6.98
CHEMBL4870317 — EC50 = 127.0 nM 6.90
CHEMBL4870713 — EC50 = 135.0 nM 6.87
CHEMBL4853653 — EC50 = 139.0 nM 6.86
CHEMBL4863475 — EC50 = 169.0 nM 6.77
CHEMBL4872750 — EC50 = 189.0 nM 6.72
CHEMBL4858153 — EC50 = 206.0 nM 6.69
CHEMBL4852555 — EC50 = 206.0 nM 6.69
CHEMBL4876494 — EC50 = 215.0 nM 6.67
CHEMBL4875018 — EC50 = 256.0 nM 6.59
CHEMBL4858538 — EC50 = 259.0 nM 6.59
CHEMBL4865925 — EC50 = 265.0 nM 6.58
CHEMBL4866211 — EC50 = 283.0 nM 6.55
CHEMBL4876049 — EC50 = 319.0 nM 6.50
CHEMBL4864546 — EC50 = 315.0 nM 6.50
CHEMBL4863958 — EC50 = 357.0 nM 6.45
CHEMBL4852351 — EC50 = 607.0 nM 6.22
CHEMBL4869052 — EC50 = 1025.0 nM 5.99
CHEMBL4855848 — EC50 = 1035.0 nM 5.99
CHEMBL4876646 — EC50 = 1128.0 nM 5.95
CHEMBL4851956 — EC50 = 1163.0 nM 5.93
CHEMBL4846767 — EC50 = 1259.0 nM 5.90
CHEMBL4867411 — EC50 = 1425.0 nM 5.85
CHEMBL4847135 — EC50 = 1693.0 nM 5.77
CHEMBL4873474 — EC50 = 1857.0 nM 5.73
CHEMBL4868734 — EC50 = 2153.0 nM 5.67
CHEMBL4873620 — EC50 = 2348.0 nM 5.63
CHEMBL4877241 — EC50 = 2539.0 nM 5.59
CHEMBL4872627 — EC50 = 2759.0 nM 5.56
CHEMBL4847633 — EC50 = 2875.0 nM 5.54
CHEMBL4851251 — EC50 = 3151.0 nM 5.50
CHEMBL128052 — EC50 > 10000.0 nM -
CHEMBL4860548 — EC50 > 10000.0 nM -
CHEMBL4868920 — EC50 > 10000.0 nM -
CHEMBL4872193 — EC50 > 10000.0 nM -
CHEMBL4860605 — EC50 > 10000.0 nM -
CHEMBL4847936 — EC50 > 10000.0 nM -
CHEMBL4871353 — EC50 > 10000.0 nM -
CHEMBL4876963 — EC50 > 10000.0 nM -
CHEMBL4868109 — EC50 > 10000.0 nM -
CHEMBL4878598 — EC50 > 10000.0 nM -
CHEMBL3127039 — EC50 > 10000.0 nM -
CHEMBL4869837 — EC50 > 10000.0 nM -