Assay Detail
Functional
CHEMBL4821227
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Antiproliferative activity against androgen-insensitive human DU-145 cells assessed as reduction in cell viability incubated for 3 days by WST-1 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An amide mimic of desTHPdactylolide: Total synthesis and antiproliferative evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.07 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL4864586 | — | — | 1 | 5.31 |
| CHEMBL4850372 | — | — | 1 | 5.07 |
| CHEMBL4845853 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4864586 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL4850372 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL4845853 | — | IC50 | = | 11100.0 | nM | 4.96 |