Assay Detail
Binding
CHEMBL4823015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP4A3
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein tyrosine phosphatase type IVA 3 (CHEMBL4162) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.13 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4445621 | — | — | 1 | 7.08 |
| CHEMBL4862721 | — | — | 1 | 6.97 |
| CHEMBL4862502 | — | — | 1 | 6.69 |
| CHEMBL4852178 | — | — | 1 | 5.94 |
| CHEMBL4864481 | — | — | 1 | 5.72 |
| CHEMBL4854258 | — | — | 1 | 5.30 |
| CHEMBL4856668 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4445621 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4862721 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4862502 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL4852178 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4864481 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4854258 | — | IC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL4856668 | — | IC50 | = | 6590.0 | nM | 5.18 |