Assay Detail
Functional
CHEMBL4823338
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.23 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866536 | — | — | 1 | 6.10 |
| CHEMBL4876405 | — | — | 1 | 6.00 |
| CHEMBL4849008 | — | — | 1 | 6.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.62 |
| CHEMBL4850081 | — | — | 1 | 5.39 |
| CHEMBL4856574 | — | — | 1 | 5.31 |
| CHEMBL4863503 | — | — | 1 | 5.28 |
| CHEMBL4872129 | — | — | 1 | 5.25 |
| CHEMBL4866591 | — | — | 1 | 5.20 |
| CHEMBL4848096 | — | — | 1 | 5.12 |
| CHEMBL4874486 | — | — | 1 | 5.12 |
| CHEMBL4863947 | — | — | 1 | 5.12 |
| CHEMBL4846633 | — | — | 1 | 5.11 |
| CHEMBL4875953 | — | — | 1 | 5.11 |
| CHEMBL4876613 | — | — | 1 | 4.95 |
| CHEMBL4870868 | — | — | 1 | 4.70 |
| CHEMBL4856406 | — | — | 1 | 4.66 |
| CHEMBL4878601 | — | — | 1 | 4.16 |
| CHEMBL4873971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866536 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4876405 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4849008 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL4850081 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL4856574 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL4863503 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4872129 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL4866591 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL4848096 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4874486 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4863947 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4846633 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4875953 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4876613 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4870868 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL4856406 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL4878601 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4873971 | — | IC50 | > | 100000.0 | nM | - |