Assay Detail
Binding
CHEMBL4824182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sterol regulatory element-binding protein 1 (CHEMBL4630818) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.88 | 6.16 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1824673 | — | — | 1 | 6.16 |
| CHEMBL4851466 | — | — | 2 | 6.14 |
| CHEMBL4876668 | — | — | 1 | 5.94 |
| CHEMBL1040 | CALCIFEDIOL ANHYDROUS | 4.0 | 1 | 5.93 |
| CHEMBL4851396 | — | — | 1 | 5.80 |
| CHEMBL1824658 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1824673 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4851466 | — | IC50 | = | 722.7 | nM | 6.14 |
| CHEMBL4876668 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL1040 | CALCIFEDIOL ANHYDROUS | IC50 | = | 1176.0 | nM | 5.93 |
| CHEMBL4851396 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1824658 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4851466 | — | Inhibition | - | % | - |