Compound Detail
CHEMBL1824658
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Basic Information
| ChEMBL ID | CHEMBL1824658 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WAUMGXOXXFKMTR-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
280.4
MW (Da)
4.74
ALogP
3
HBA
0
HBD
25.8
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sterol regulatory element-binding protein 1 CHEMBL4630818 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
| Sterol regulatory element-binding protein 2 CHEMBL1795166 | IC50 | 5.17 | 5.17 | 6800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sterol regulatory element-binding protein 1 | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase rep... | 33899473 |
| Sterol regulatory element-binding protein 2 | IC50 | = | 6800.0 | nM | 5.17 | Inhibition of SREBP2 activation expressed in CHO-K1 cells co-transfected with pS... | 21561152 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21561152 | 10.1021/jm200304y | Sterol regulatory element-binding protein 2 | 1 |
| 33899473 | 10.1021/acs.jmedchem.0c02179 | Sterol regulatory element-binding protein 1 | 1 |
Data from ChEMBL 36 via Core Engine