Assay Detail
Binding
CHEMBL4825145
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Inhibition of recombinant equine BChE by Ellman's method
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of γ-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.38 | 8.10 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848411 | — | — | 1 | 8.10 |
| CHEMBL4864593 | — | — | 1 | 8.10 |
| CHEMBL4850804 | — | — | 1 | 7.96 |
| CHEMBL4855045 | — | — | 1 | 7.80 |
| CHEMBL4873748 | — | — | 1 | 7.50 |
| CHEMBL4874126 | — | — | 1 | 7.50 |
| CHEMBL4850585 | — | — | 1 | 7.43 |
| CHEMBL4878924 | — | — | 1 | 7.39 |
| CHEMBL4870561 | — | — | 1 | 7.39 |
| CHEMBL4860501 | — | — | 1 | 6.77 |
| CHEMBL4863376 | — | — | 1 | 6.26 |
| CHEMBL596112 | — | — | 1 | 6.05 |
| CHEMBL12540 | — | — | 1 | 5.92 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.89 |
| CHEMBL261855 | — | — | 1 | 5.85 |
| CHEMBL4856643 | — | — | 1 | 5.85 |
| CHEMBL4850464 | — | — | 1 | 5.72 |
| CHEMBL4859070 | — | — | 1 | 5.68 |
| CHEMBL4849276 | — | — | 1 | 5.57 |
| CHEMBL4865927 | — | — | 1 | 5.26 |
| CHEMBL4849640 | — | — | 1 | 5.20 |
| CHEMBL1712867 | — | — | 1 | 5.19 |
| CHEMBL1984135 | — | — | 1 | 5.19 |
| CHEMBL4857977 | — | — | 1 | 5.01 |
| CHEMBL4846730 | — | — | 1 | 4.90 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848411 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4864593 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4850804 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4855045 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4873748 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4874126 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4850585 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4878924 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4870561 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4860501 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4863376 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL596112 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL12540 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL261855 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4856643 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4850464 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4859070 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4849276 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4865927 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4849640 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1712867 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1984135 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4857977 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4846730 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL807 | MEMANTINE | Inhibition | < | 50.0 | % | - |