Assay Detail
Binding
CHEMBL4825231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATAD2 (unknown origin) by TR-FRET assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATPase family AAA domain-containing protein 2 (CHEMBL2150837) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.50 | 6.20 |
| pIC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860188 | — | — | 1 | 6.20 |
| CHEMBL4878541 | — | — | 1 | 6.00 |
| CHEMBL4868866 | — | — | 1 | 5.90 |
| CHEMBL3585461 | — | — | 1 | 5.80 |
| CHEMBL3585452 | — | — | 1 | 5.70 |
| CHEMBL4865495 | — | — | 1 | 5.70 |
| CHEMBL4855456 | — | — | 1 | 5.60 |
| CHEMBL4857270 | — | — | 1 | 5.00 |
| CHEMBL4872504 | — | — | 1 | 5.00 |
| CHEMBL4856376 | — | — | 1 | 4.90 |
| CHEMBL4850335 | — | — | 1 | 4.70 |
| CHEMBL4862754 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860188 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4878541 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4868866 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL3585461 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3585452 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4865495 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4855456 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4857270 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4872504 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4856376 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4850335 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL4862754 | — | pIC50 | - | — | - |