Compound Detail
CHEMBL4878541
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4878541 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YKDUUWMPYBJPOG-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
406.5
MW (Da)
2.83
ALogP
6
HBA
3
HBD
99.9
PSA (Ų)
0.58
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transcription initiation factor TFIID subunit 1 CHEMBL3217390 | IC50 | 7.3 | 7.3 | 50.1 | 1 |
| ATPase family AAA domain-containing protein 2 CHEMBL2150837 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Bromodomain-containing protein 4 CHEMBL1163125 | IC50 | 5.6 | 5.6 | 2511.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transcription initiation factor TFIID subunit 1 | IC50 | = | 50.12 | nM | 7.3 | Inhibition of TAF1 bromodomain 2 (unknown origin) by TR-FRET assay | 34413961 |
| ATPase family AAA domain-containing protein 2 | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of ATAD2 (unknown origin) by TR-FRET assay | 34413961 |
| Bromodomain-containing protein 4 | IC50 | = | 2511.89 | nM | 5.6 | Inhibition of BRD4 BD1 (unknown origin) by TR-FRET assay | 34413961 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34413961 | 10.1021/acsmedchemlett.1c00294 | Unchecked | 2 |
| 34413961 | 10.1021/acsmedchemlett.1c00294 | No relevant target | 2 |
| 34413961 | 10.1021/acsmedchemlett.1c00294 | Transcription initiation factor TFIID subunit 1 | 1 |
| 34413961 | 10.1021/acsmedchemlett.1c00294 | Bromodomain-containing protein 4 | 1 |
| 34413961 | 10.1021/acsmedchemlett.1c00294 | ATPase family AAA domain-containing protein 2 | 1 |
| 34413961 | 10.1021/acsmedchemlett.1c00294 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine