Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4825887

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Respiratory syncytial virus A2 infected in African green monkey Vero cells by Plaque reduction assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human respiratory syncytial virus
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Human orthopneumovirus (CHEMBL613127)
Type ORGANISM
Organism Human orthopneumovirus

Publication

Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.
Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K.
J Med Chem (2021) 64 : 3658 -3676
PubMed 33729773 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 21 6.86 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4878302 1 9.10
CHEMBL4297497 SISUNATOVIR 2.0 1 8.89
CHEMBL4872095 1 8.38
CHEMBL4876843 1 8.27
CHEMBL4865906 1 8.17
CHEMBL4859694 1 7.75
CHEMBL4872263 1 7.59
CHEMBL4469438 1 7.51
CHEMBL4860271 1 7.39
CHEMBL4862291 1 6.74
CHEMBL4845727 1 6.62
CHEMBL4877602 1 6.51
CHEMBL4850153 1 6.35
CHEMBL4869353 1 6.34
CHEMBL4874044 1 6.24
CHEMBL4855486 1 5.77
CHEMBL4878086 1 5.62
CHEMBL4851012 1 5.47
CHEMBL4873987 1 5.44
CHEMBL4878851 1 4.99
CHEMBL4868500 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4878302 EC50 = 0.8 nM 9.10
CHEMBL4297497 SISUNATOVIR EC50 = 1.3 nM 8.89
CHEMBL4872095 EC50 = 4.2 nM 8.38
CHEMBL4876843 EC50 = 5.4 nM 8.27
CHEMBL4865906 EC50 = 6.7 nM 8.17
CHEMBL4859694 EC50 = 17.9 nM 7.75
CHEMBL4872263 EC50 = 25.4 nM 7.59
CHEMBL4469438 EC50 = 31.0 nM 7.51
CHEMBL4860271 EC50 = 40.8 nM 7.39
CHEMBL4862291 EC50 = 180.7 nM 6.74
CHEMBL4845727 EC50 = 240.0 nM 6.62
CHEMBL4877602 EC50 = 310.0 nM 6.51
CHEMBL4850153 EC50 = 444.2 nM 6.35
CHEMBL4869353 EC50 = 453.9 nM 6.34
CHEMBL4874044 EC50 = 580.0 nM 6.24
CHEMBL4855486 EC50 = 1700.0 nM 5.77
CHEMBL4878086 EC50 = 2384.3 nM 5.62
CHEMBL4851012 EC50 = 3400.0 nM 5.47
CHEMBL4873987 EC50 = 3636.0 nM 5.44
CHEMBL4878851 EC50 = 10181.3 nM 4.99
CHEMBL4868500 EC50 = 14000.0 nM 4.85