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Assay Detail

CHEMBL4827162

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells by Alamar blue assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

New antiparasitic flexible triaryl diamidines, their prodrugs and aza analogues: Synthesis, in vitro and in vivo biological evaluation, and molecular modelling studies.
Arafa RK, Ismail MA, Wenzler T, Brun R, Paul A, Wilson WD, Alakhdar AA, Boykin DW.
Eur J Med Chem (2021) 222 : 113625 -113625
PubMed 34146914 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.82 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4875142 1 5.96
CHEMBL4859955 1 5.70
CHEMBL4862097 1 5.68
CHEMBL4854237 1 5.40
CHEMBL24057 FURAMIDINE -1.0 1 5.19
CHEMBL4877388 1 4.74
CHEMBL4849091 1 4.71
CHEMBL4867511 1 4.60
CHEMBL4877093 1 4.55
CHEMBL4878609 1 4.49
CHEMBL4867790 1 4.46
CHEMBL4865149 1 4.43
CHEMBL55 PENTAMIDINE 4.0 1 4.34
CHEMBL4846149 1 4.04
CHEMBL298415 1 4.00
CHEMBL4850544 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4875142 IC50 = 1100.0 nM 5.96
CHEMBL4859955 IC50 = 2000.0 nM 5.70
CHEMBL4862097 IC50 = 2100.0 nM 5.68
CHEMBL4854237 IC50 = 4000.0 nM 5.40
CHEMBL24057 FURAMIDINE IC50 = 6400.0 nM 5.19
CHEMBL4877388 IC50 = 18100.0 nM 4.74
CHEMBL4849091 IC50 = 19400.0 nM 4.71
CHEMBL4867511 IC50 = 25000.0 nM 4.60
CHEMBL4877093 IC50 = 28300.0 nM 4.55
CHEMBL4878609 IC50 = 32300.0 nM 4.49
CHEMBL4867790 IC50 = 34800.0 nM 4.46
CHEMBL4865149 IC50 = 37300.0 nM 4.43
CHEMBL55 PENTAMIDINE IC50 = 46000.0 nM 4.34
CHEMBL4846149 IC50 = 91000.0 nM 4.04
CHEMBL298415 IC50 = 99300.0 nM 4.00
CHEMBL4850544 IC50 = 116600.0 nM -