Assay Detail
Functional
CHEMBL4830279
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Anticancer activity against human Jurkat cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 reagent assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.86 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856545 | — | — | 1 | 6.32 |
| CHEMBL4854960 | — | — | 1 | 6.19 |
| CHEMBL4854240 | — | — | 1 | 6.11 |
| CHEMBL4859691 | — | — | 1 | 6.03 |
| CHEMBL4862637 | — | — | 1 | 5.67 |
| CHEMBL4864991 | — | — | 1 | 5.44 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 5.28 |
| CHEMBL504767 | — | — | 1 | - |
| CHEMBL4857682 | — | — | 1 | - |
| CHEMBL4854516 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
| CHEMBL4847328 | — | — | 1 | - |
| CHEMBL4848313 | — | — | 1 | - |
| CHEMBL4878793 | — | — | 1 | - |
| CHEMBL4847197 | — | — | 1 | - |
| CHEMBL4858752 | — | — | 1 | - |
| CHEMBL4865727 | — | — | 1 | - |
| CHEMBL4854462 | — | — | 1 | - |
| CHEMBL4857828 | — | — | 1 | - |
| CHEMBL4858826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856545 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4854960 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4854240 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4859691 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4862637 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4864991 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL504767 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4857682 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4854516 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | < | 10.0 | nM | - |
| CHEMBL4847328 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4848313 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4878793 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4847197 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4858752 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4865727 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4854462 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4857828 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4858826 | — | IC50 | > | 10000.0 | nM | - |