Assay Detail
Binding
CHEMBL4831259
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Inhibition of PI3K/Akt/mTOR pathway in human MDA-MB-468 cells assessed as reduction in S6 phosphorylation incubated for 15 to 20 mins by Alexa Fluor 488 staining based assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.54 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3675442 | — | — | 1 | 10.10 |
| CHEMBL4878044 | — | — | 1 | 8.80 |
| CHEMBL3680521 | — | — | 1 | 8.04 |
| CHEMBL4871106 | RUPITASERTIB | 2.0 | 1 | 7.96 |
| CHEMBL3675415 | — | — | 1 | 7.60 |
| CHEMBL4855657 | — | — | 1 | 7.60 |
| CHEMBL4871853 | — | — | 1 | 7.55 |
| CHEMBL4846712 | — | — | 1 | 7.37 |
| CHEMBL4856439 | — | — | 1 | 7.37 |
| CHEMBL3685329 | — | — | 1 | 7.35 |
| CHEMBL4876446 | — | — | 1 | 7.25 |
| CHEMBL4854144 | — | — | 1 | 7.14 |
| CHEMBL4860970 | — | — | 1 | 7.13 |
| CHEMBL4851020 | — | — | 1 | 7.12 |
| CHEMBL4875416 | — | — | 1 | 6.99 |
| CHEMBL4869229 | — | — | 1 | 6.74 |
| CHEMBL4846770 | — | — | 1 | 6.15 |
| CHEMBL4857965 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3675442 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL4878044 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3680521 | — | IC50 | = | 9.17 | nM | 8.04 |
| CHEMBL4871106 | RUPITASERTIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3675415 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4855657 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4871853 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4846712 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4856439 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3685329 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4876446 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4854144 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4860970 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4851020 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4875416 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4869229 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4846770 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL4857965 | — | IC50 | > | 1000.0 | nM | - |