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Assay Detail

CHEMBL4833207

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as protection against virus-induced cytopathic effect incubated for 5 days by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.
Huang B, Ginex T, Luque FJ, Jiang X, Gao P, Zhang J, Kang D, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.
J Med Chem (2021) 64 : 13604 -13621
PubMed 34496571 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 7.64 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL175691 RILPIVIRINE 4.0 1 9.00
CHEMBL4855307 1 8.77
CHEMBL223228 EFAVIRENZ 4.0 1 8.35
CHEMBL308954 ETRAVIRINE 4.0 1 8.32
CHEMBL4851873 1 8.21
CHEMBL4861514 1 8.15
CHEMBL4876956 1 8.12
CHEMBL4860247 1 8.11
CHEMBL4875519 1 7.97
CHEMBL4865966 1 7.93
CHEMBL4866808 1 7.90
CHEMBL2364608 DORAVIRINE 4.0 1 7.89
CHEMBL4877758 1 7.85
CHEMBL4861244 1 7.75
CHEMBL4847927 1 7.46
CHEMBL4849718 1 7.45
CHEMBL4861165 1 7.44
CHEMBL4867738 1 7.41
CHEMBL4853708 1 7.33
CHEMBL4869780 1 7.25
CHEMBL4848837 1 7.09
CHEMBL4857899 1 6.63
CHEMBL4868137 1 6.60
CHEMBL4861640 1 6.09
CHEMBL4852687 1 5.97
CHEMBL4847461 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL175691 RILPIVIRINE EC50 = 1.0 nM 9.00
CHEMBL4855307 EC50 = 1.7 nM 8.77
CHEMBL223228 EFAVIRENZ EC50 = 4.5 nM 8.35
CHEMBL308954 ETRAVIRINE EC50 = 4.8 nM 8.32
CHEMBL4851873 EC50 = 6.1 nM 8.21
CHEMBL4861514 EC50 = 7.0 nM 8.15
CHEMBL4876956 EC50 = 7.6 nM 8.12
CHEMBL4860247 EC50 = 7.7 nM 8.11
CHEMBL4875519 EC50 = 10.6 nM 7.97
CHEMBL4865966 EC50 = 11.7 nM 7.93
CHEMBL4866808 EC50 = 12.6 nM 7.90
CHEMBL2364608 DORAVIRINE EC50 = 13.0 nM 7.89
CHEMBL4877758 EC50 = 14.0 nM 7.85
CHEMBL4861244 EC50 = 17.7 nM 7.75
CHEMBL4847927 EC50 = 35.1 nM 7.46
CHEMBL4849718 EC50 = 35.4 nM 7.45
CHEMBL4861165 EC50 = 36.3 nM 7.44
CHEMBL4867738 EC50 = 38.6 nM 7.41
CHEMBL4853708 EC50 = 46.9 nM 7.33
CHEMBL4869780 EC50 = 56.7 nM 7.25
CHEMBL4848837 EC50 = 80.6 nM 7.09
CHEMBL4857899 EC50 = 234.0 nM 6.63
CHEMBL4868137 EC50 = 253.0 nM 6.60
CHEMBL4861640 EC50 = 820.0 nM 6.09
CHEMBL4852687 EC50 = 1072.0 nM 5.97
CHEMBL4847461 EC50 > 93881.0 nM -